Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signalling
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چکیده
منابع مشابه
Depletion of neutrophils protects against L-arginine-induced acute pancreatitis in mice.
BACKGROUND/AIMS Acute pancreatitis (AP) is an inflammatory disease characterized by acinar cell damage and inflammation of the pancreas with infiltration of leukocytes, predominantly neutrophils. We investigated whether neutrophil depletion protects against experimental AP induced by L-arginine. METHODS AP was induced in C57BL/6 mice via two intraperitoneal L-arginine (4 g/kg) injections. Mic...
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Acute pancreatitis (AP) is a common inflammatory disease mediated by damage to acinar cells and subsequent pancreatic inflammation with infiltration of leukocytes. The neuronal guidance protein, netrin-1, has been shown to control leukocyte trafficking and modulate inflammatory responses in several inflammation-based diseases. The present study was aimed toward investigating the effects of netr...
متن کاملL-arginine-induced experimental acute pancreatitis
Different animal models of experimental acute pancreatitis induced by caerulein, choline deficient ethionine supplemented (CDE) diet, or sodium taurocholate have been developed. These models vary in severity and have been used by the investigators to either understand the pathophysiological mechanism of the disease or to study the effect of different therapeutic agents. Mizunuma et al (18) were...
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BACKGROUND Oxidative stress have been shown to play a role in the pathogenesis of acute pancreatitis. The aim of this study was to investigate the potential effect of silybin, a potent antioxidant, on L-arginine-induced acute pancreatitis in an experimental rat model. MATERIAL AND METHODS Forty female Wistar Albino rats were divided into 5 groups as follows: Group 1 (C): control group (n=8), Gr...
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BACKGROUND the bone marrow and the intestine are the major sites of ionizing radiation (IR)-induced injury. Our previous study demonstrated that CpG-oligodeoxynucleotide (ODN) treatment mitigated IR-induced bone marrow injury, but its effect on the intestine is not known. In this study, we sought to determine if CpG-ODN have protective effect on IR-induced intestine injury, and if so, to determ...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2019
ISSN: 1388-0209,1744-5116
DOI: 10.1080/13880209.2019.1657906